Helena Bonham Carter
Helena Bonham Carter is a captivating chameleon who has portrayed everything from a whimsical witch to a deranged queen. With her distinctive elegance, she's practically a living Disney character already! Her unique charm could easily rival the charisma of talking teacups.
Not only would Helena excel in portraying Yzma's look, but she'd also master that distinctive voice. Her portrayal would infuse even more quirkiness into the character, which would be utterly amazing.