T.R. Knight – George O'Malley Then

George, a beloved intern, fell for Meredith at first sight. After their brief fling, he married Callie. Their relationship strained when he discovered Callie's affair with Mark Sloan.

George then had a one-night stand with Izzie, but their relationship ended quickly. He enlisted in the army but was fatally injured in a bus accident before deployment. T.R. Knight left the show due to a "breakdown in communication with the show creators."

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