T.R. Knight – George O'Malley Then
George, a beloved intern, fell for Meredith at first sight. After their brief fling, he married Callie. Their relationship strained when he discovered Callie's affair with Mark Sloan.
George then had a one-night stand with Izzie, but their relationship ended quickly. He enlisted in the army but was fatally injured in a bus accident before deployment. T.R. Knight left the show due to a "breakdown in communication with the show creators."