Justin Chambers – Alex Karev Then
Alex was introduced as a rude intern at Seattle Grace Hospital, but his brilliance in pediatrics made him an invaluable asset to the hospital. Despite his rough start, he quickly proved his medical talents, especially when working with children. Throughout his time at the hospital, Alex was involved with several key characters, including Izzie Stevens, Meredith Grey, and Jo Wilson, whom he ultimately married.
However, Alex's life took a surprising turn when he discovered that Izzie had secretly given birth to his children. This revelation led him to make the difficult decision to leave Seattle and be with his newfound family. After 15 years on the show, Justin Chambers, who portrayed Alex, decided to depart, marking the end of an era for this beloved character.